Doctoral Researcher (f/div/m) Synthetic Biology of Therapeutic Microbes

Einsatzort: Jena

Job Advertisement HKI-34/2020

The Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute (Leibniz-HKI, investigates the pathobiology of human-pathogenic fungi and identifies targets for the development of novel natural product-based antibiotics. The Junior Research Group Synthetic Microbiology invites talented and highly gifted candidates to apply as a

Doctoral Researcher (f/div/m) Synthetic Biology of Therapeutic Microbes

starting from January 1st 2021.

Research Areas:

  • Synthetic Biology, Biomedical Engineering, Microbiology
  • This project will address the engineering of probiotic microorganisms into Therapeutic Microbes for the diagnosis and treatment of infectious diseases.

The field of work might include:

  • Evaluation and genetic optimization of diverse probiotic organisms for biomedical applications (chassis design)
  • Selection and engineering of sensing, adhesion and effector proteins
  • Optimization of biosynthetic pathways
  • Construction of synthetic regulatory gene circuits
  • Directed evolution
  • Bioassays for determination of anti-virulence activity


Main requirements:

• Degree and excellent experience in biotechnology, microbiology, biochemistry, metabolic engineering or related disciplines. Candidates about to obtain their degree are welcomed to apply.

• Advanced experience in molecular biology and genetic engineering of bacteria or yeasts

• Experience in microbial (co-)cultivations

• The candidate should be willing and able to work in an international, interdisciplinary research team

• Ability for team-oriented as well as creative and independent work

• Very good communication skills in English

Preferred Skills:

• Skills in protein science (protein purification, Western Blot, etc.)

• Experience in biochemistry (enzymatic reactions) and microtiter plate-based assays

• Experience in analytical methods (HPLC, LC-MS etc.)

• Good knowledge in microscopy and/or microfluidics techniques is advantageous

We offer:

The successful candidate will be hosted in the independent Junior Research Group "Synthetic Microbiology" headed by Dr. Gerald Lackner. The group conducts innovative cutting-edge research by combining synthetic biology with natural product research and infection biology. The Leibniz-HKI is embedded in the outstanding scientific environment of the Beutenberg Campus providing state-of-the-art research facilities and a highly integrative network of life science groups. We offer a multifaceted scientific project supported by excellent technical facilities a place in a young, committed team, as well as strong scientific collaborations. The PhD candidate will participate in the structured program of the International Leibniz Research School and become an associated member of the Jena School of Microbial Communication.

Salary is paid according to German TV-L (salary agreement for public service employees). As an equal opportunity employer, the Leibniz-HKI is committed to increasing the percentage of female scientists and therefore especially encourages them to apply.

Further information

Further information:

Dr. Gerald Lackner | +49 3641 532 1104 |


Complete applications in English should include a CV, a complete list of publications, a brief statement of research experiences, the addresses of two possible referees, and should be submitted by September 30th, 2020, via the Leibniz-HKI online application system.