PhD position in theoretical biophysics, computer simulations of RNA regulation

Einsatzort: Frankfurt am Main

MPI

Art der Stelle

PhD position in theoretical biophysics, computer simulations of RNA regulation

Stellenangebot vom 11.03.2019

The Max Planck Institute of Biophysics, Department of Theoretical Biophysics (Director Gerhard Hummer) has one open PhD position,
"Regulating RNA by Cations: Insights from Molecular Dynamics Simulations"within the Emmy Noether Research Group (Dr. Nadine Schwierz-Neumann).

Our project

The work focuses on the theoretical description of the interaction between RNA and metal cations using computer simulations and methods from statistical physics.
Positively charged cations are essential for the stability and function of RNA. In particular, changes in the local salt concentration or the type of cations present in solution immediately influence RNA regulatory elements and their regulatory functions.

In the PhD project, molecular dynamics simulations will be applied to elucidate the fundamental interplay of cations and RNA regulation. The work will focus on two important RNA regulatory elements: An RNA G-quadruplex and the guanidine-II riboswitch.

In the PhD project, molecular dynamics simulations and enhanced sampling techniques will be applied in order to provide microscopic insights into the mechanism underlying RNA regulation. In order to gain a comprehensive view, we combine the computational methods with NMR and time-resolved spectroscopy experiments (performed by our collaborators at the Goethe University).

Requirements

Candidates with background in statistical and soft matter physics and expertise in methods such as all-atom molecular dynamics simulations, high performance computing, advanced sampling techniques, and programming are highly encouraged to apply.

The Max Planck Society is committed to employ more disabled persons. The application of disabled persons is strongly encouraged. The Max Planck Society is committed to increase the number of female scientists. Women are particularly encouraged to apply.

Our

Our offer

The salary will be paid according to the collective agreement for civil service employees (TVöD, 65%, E13).
The Max Planck Society is committed to employ more disabled persons. The application of disabled persons is strongly encouraged. The Max Planck Society is committed to increase the number of female scientists. Women are particularly encouraged to apply.

Your application

Review of applications will start immediately and continue until the position is filled. Start date is June 1st, 2019, early-bird applications are welcome. Please send your application including CV, cover letter, and the names of at least one referee in electronic form as a single pdf-file to

Dr. Nadine Schwierz-Neumann
Emmy Noether Research Group Leader

Max-Planck-Institut für Biophysik,
Abteilung für Theoretische Biophysik
Max-von-Laue-Str. 3
60438 Frankfurt am Main
Deutschland