- Developmental and Evolutionary Biology & Genetics
- Immunobiology and Infection Biology & Medicine
- Structural and Cell Biology
Art der Stelle
Postdoctoral Associate / Staff Scientist Computational Biology (m/f/d)
Stellenangebot vom 19.08.2022
The Max Planck Institute for Molecular Genetics in Berlin is an international research institute with approx. 350 employees, working in the field of molecular genetics. A special focus lies on functional genomics of man and other organisms.
The research group of Prof. Dr. Vallier offers an open fulltime position: Postdoctoral Associate / Staff Scientist Computational Biology (m/f/d), E13/14 according to the TVöD salary scale.
We are looking for a highly motivated and enthusiastic stem cell biologist to uncover the mechanism directing the functional maturation of hepatocytes during liver development. More precisely, we will exploit existing Single Cell RNA-Seq data set to identify pathways and transcription factors directing the progressive acquisition of hepatic functions during human development. Of note, the necessary data set are already available and ready to be used for this project. The uncovered mechanisms will be validating by performing gain and loss of functions experiments on hepatoblast organoids recently described (https://doi.org/10.1101/2022.03.08.482299) and on animal models. Molecular analyses will reveal the downstream and up-stream pathways directing liver organogenesis especially the transcriptional regulations leading to the sequential expression of functional genes during hepatic development. This knowledge will be ultimately used to improve the functionality of human Induced Pluripotent Stem Cells (hIPSCs) derived hepatocytes for cell-based therapy applications.
The successful candidate will be a passionate individual with the ability to learn and to adapt to competitive environments. A PhD or a similar qualification in stem cell biology is required. Strong experience in tissue culture especially with in human pluripotent stem and/or organoids derived from primary tissue is necessary. Solid background in liver development and liver biology would also be appreciated.
Example project spaces include:
- Identify genes and pathways directing liver organogenesis by analysing single cell RNA-Seq in collaboration with bio-informatic core facility
- Grow, differentiate and characterize primary organoid and human induced pluripotent stem cells in different cell types including hepatocytes.
- Perform functional validations in animal models.
The Max Planck Institute for Molecular Genetics in Berlin is the flagship institute of the Max Planck Society for genome research, offering an internationally competitive research environment and cutting edge infrastructure for genomics and big data tools. The institute is located in Berlin, a thriving European capitol, and offers competitive salaries and social benefits.
The position is limited for 3 years. It is available as of now but starting dates are negotiable.
The Max-Planck Society is committed to increasing the number of individuals with disabilities in its workforce and therefore encourages applications from such qualified individuals. Furthermore, the Max Planck Society seeks to increase the number of women in those areas where they are underrepresented and therefore explicitly encourages women to apply.
Interested candidates should submit their application including (i) a brief cover letter (describing your motivation), (ii) a CV, (iii) contact information of 2-3 references via our external application system. Further inquires are also welcome.