Research Position Bioinformatics (all genders) (96/20)

Einsatzort: Berlin

Founded in 1891, the Robert Koch Institute (RKI) is one of the world's oldest biomedical research institutions. Today, the RKI is Germany's national public health institute. It employs more than 1,300 people, provides excellent research infrastructure and pursues a modern approach to its scientific work.

We are offering the following position in unit MF 1 "Bioinformatics" of department MF "Methodology and Research Infrastructure" for a

Research Position Bioinformatics (all genders) (96/20)

closing date: November 30, 2020

start of work: as soon as possible

hours of work: part time

Research Position Bioinformatics (all genders) (96/20)

(salary in accordance with public sector wage scale E 13 TVöD). The contract is limited until 31 July 2025. The position will be available immediately.

HIV-1 pre-exposure prophylaxis (PrEP) is a novel anti-retroviral based strategy to prevent HIV infection. The goal of the BMBF-funded project Trans-PrEP is to establish- and refine integrative modelling and simulation tools to estimate the clinical efficacy of HIV-1 pre-exposure prophylaxis based on in vitro/cellular and explant pharmacological- and virological data. The project funds 4 full-time scientists. The specific focus of the post-doc is to elucidate the mechanisms of action of PrEP in different risk groups (e.g. male vs. female).

Tasks

  • Develop & implement pharmacometric models (ODE), as well as viral kinetic models (Markov) and perform hybrid simulations to predict clinical efficacy of PrEP
  • Develop algorithms for computing extinction probabilities (inhom. Markov Processes)
  • Study drug resistance development in next-generation long-acting PrEP
  • Publication and presentation of results
  • Cooperation with internal- and external partners (Johns Hopkins, Harvard Med, ITM Liverpool, UC Colorado, Bill & Melinda Gates HIV Modelling Consortium)
  • Training, support and supervision of young researchers and research scientists

Your profile

  • University degree in Natural Science (Master's level, Diploma) for instance (Bio-) Informatics, Mathematics, Statistics, Physics, Biology; PhD in a related field
  • Working experience in Computational Systems Biology or related field
  • Knowledge in Computational Systems Biology and/or Pharmacometrics
  • Good level in programing and familiarity with software development techniques
  • Knowledge in modelling and simulation techniques
  • Advanced knowledge and practical experience in at least ONE of the following areas:Inverse problems/parameter estimation
    Biostatistics/statistical analysis
    Data analysis and integration
    Microbiology and Infection biology
  • Experience in drafting scientific publications
  • Experience in the collaborative work with experimental research groups, in particular the capacity to translate the biological questions in a bioinformatics application
  • Languages (CEFR-Level): English at least C1 (expert knowledge), Elementary knowledge (A2) in German would be a plus

You attach great importance to a work environment that demands your own ideas and initiative. You can independently develop complex projects, implement them responsibly and lead them with perseverance successfully to their goal. Communication on equal terms is important. You can identify communication barriers, solve them and adapt well to maintaining cooperation with various partners.

Please note that in single cases the Federal Ministry of Health may access your application documents to ensure appropriate personnel selection within its scope as supervisory authority. Your data will be deleted immediately after the completion of the application process.

The RKI is located in Berlin - Germany's vibrant, multicultural capital in the heart of Europe. The Institute's facilities are set in the environment of a clean, green city that is home to first class art, historical and science museums and well-known theatres. Public transit links to other districts and the surrounding countryside are excellent.

The RKI offers flexible work hours and terms of employment that promote in as far as possible employee life-work balance. Education and training are also provided based on employee needs. The RKI also has a comprehensive health maintenance program and assists incoming staff members and their families in settling in their new location.

The RKI is an affirmative action, equal opportunity employer.

Application procedure

Submit your application via the public service job portal Interamt at www.interamt.de by 30 November 2020. Please note the position identification number: 623660 (StellenID)/Kz. 96/20.